authors
-
Artur Dembiński, Andrzej Bugajski
- Z Katedry i Kliniki Urologii AM w Krakowie Kierownik: prof. zw. dr med. J. Leńko Z Instytutu Fizjologii AM w Krakowie Kierownik: prof. dr med. St. Konturek
summary
- The effect of the epidermal growth factor (EGF) on the growth of ureteral mucosa was studied in rats. The method of surgical removal of salivary glands was used. The EGF levels were determined in the serum and urine. The weight of the ureters and the levells of RNA and DNA were decreased after removal of the salivary glands. These changes were reversible after hormone administration. The observed Changes were reverisible after the administration of the hormone. The observed changes were associated with parallel EGF changes in the serum and urine. The obtained results indicate a high physiological role of EGF in the regulation of ureteral mucosa regeneration. The effects of hormone action suggest a possibility of clinical use of the hormone.
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