PTU - Polskie Towarzystwo Urologiczne
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EPIDERMAL GROWTH FACTOR EFFECT ON THE REGENERATION OF URETERAL MUCOSA
Article published in Urologia Polska 1986/39/3.

authors

Artur Dembiński, Andrzej Bugajski
Z Katedry i Kliniki Urologii AM w Krakowie Kierownik: prof. zw. dr med. J. Leńko Z Instytutu Fizjologii AM w Krakowie Kierownik: prof. dr med. St. Konturek

summary

The effect of the epidermal growth factor (EGF) on the growth of ureteral mucosa was studied in rats. The method of surgical removal of salivary glands was used. The EGF levels were determined in the serum and urine. The weight of the ureters and the levells of RNA and DNA were decreased after removal of the salivary glands. These changes were reversible after hormone administration. The observed Changes were reverisible after the administration of the hormone. The observed changes were associated with parallel EGF changes in the serum and urine. The obtained results indicate a high physiological role of EGF in the regulation of ureteral mucosa regeneration. The effects of hormone action suggest a possibility of clinical use of the hormone.

references

  1. 1. Burton H.: A study of the conditions and mechanism of the diphenylamine
  2. reaction for the colorimetric estimation of deoxyribonucleotic acid. Biochem. J.,
  3. 1956, 62, 315. ? 2. Bynny R. L., Orth D. N.: Epidermal growth factor: effects
  4. of androgens and adrenic agents. Endocrinology, 1974, 95, 776. ? 3. Ceriotti G.:
  5. Determination of nucleic acids in animals tissues. J. Biol. Chem., 1955, 214, 59. ?
  6. 4. Cohen S.: Isolation of a mouse submaxillary gland protein accelerating incisor
  7. eruption and eyelid opening in the new-born animal. J. biol. Chem., 1972, 237,
  8. 1155. ? 5. Cohen S., Savage C. R.: Recent studies on the chemistry and biology
  9. of epidermal growth factor. Recent Prog. Horm. Res., 1974, 30, 531. ? 6. Dembiń­
  10. ski A., Gregory H., Konturek S. J., Polański M.: Trophic action of epidermal
  11. growth factor on the pancreas and gastroduodenal mucosa in rat. J. Physiol. Lond.,
  12. 1982, 325, 35, ? 7. Doiley G. E., Kraus J W., Orth D. N.: Homologus radioimmuno-
  13. assay for human epidermal growth factor (urogastrone). J. clin. Endocr. Metab.,
  14. 1978, 46, 929. ? 8. Elder J. B., Williams G., Lacey E., Gregory H.: Cellular loca-
  15. lization of human urogastrone epidermal growth factor. Nature, Lond., 1978, 271,
  16. 466. ? 9. Giles K. W., Myers A,: An improved diphenylamine method for the
  17. estimation of deoxyribonucleic acid. Nature, Lond., 1975, 206, 93. ? 10. Gregory H.:
  18. Isolation and structure of urogastrone and its relationship to epidermal growth
  19. factor. Nature, Lond., 1975, 257, 325.
  20. 11. Hollenberg M. D., Gregory H.: Human urogastrone and mouse epidermal
  21. growth factor ahare a common receptor. Life Sci., 1976, 20, 267. ? 12. Imai Y.,
  22. Tsuhima T., Sazaki N., Matsuzaki F.: Radioreceptor assay for epidermal growth
  23. factor, growth and growth factors. Shizuka K. and Takano K. University Park
  24. Press. 1979. ? 13. Olsen S. P., Nexo E.: Quantitation of epidermal growth factor
  25. in the rat. Identification and partial characterization of duodenal EGF. Scand. J.
  26. Gastroent., 1983, 18, 771. ? 14. Starkey R. H., Orth D. N.: Radioimmunoassay of
  27. human epidermal growth factor (urogastrone). J. clin. Endocr. Metab., 1978, 46, 929.