PTU - Polskie Towarzystwo Urologiczne
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THE INFLUENCE OF SURGERY OF KIDNEYS ON THE PHARMACOKINETICS OF GENTAMICIN IN RABBITS
Article published in Urologia Polska 1989/42/2.

authors

Stanisław Dyderski
Z Zakładu Farmacji Klinicznej Akademii Medycznej w Poznaniu Kierownik Zakładu: prof. dr hab. farm. J. Masiakowski

summary

The author determined the gentamicin concentration in rabbit serum after i.m. administering 10 mg in Control group A, in group of unilateral nephrectomy B on the 14th day after nephrectomy ? group C, after cooling a kidney down to 15°C for 30 min. ? group D, and after 14 days of ischaemia and cooling kidney ? group E. On the grounds of the concentrations measured, the author calculated pharmacokinetic parameters. The Comparison of the parameters made it possible to evaluate the influence of surgery on a kidney function.

references

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