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EPITESTOSTERONE ? AN ENDOGENOUS ANTIANDROGEN
Article published in Urologia Polska 1996/49/3.

authors

Marek Mędra¶, Andrzej Basiewicz
Z Katedry i Kliniki Endokrynologii A.M. we Wrocławiu
Kierownik: Prof. dr hab. med. A.Milewicz

keywords

prostate epitestosterone

summary

The paper presents epitestosterone which has been believed as a metabolite without
any hormonal activity. Recent studies showed that a complex action of epitestosterone
consists of competitive binding to androgen receptor, of inhibition of testosterone bio-
synthesis and its reduction to dihydrotestosterone and of antigonadotropic activity.
Authors conclude that epitestosterone is effective as an antiandrogen and can contri-
bute to the regulation of androgen dependent organs especially prostate.

references

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