authors
-
Anna Kołodziej, Danuta Duś, Janusz Dembowski, Tadeusz Niezgoda, Bogdana Dąbrowska, Jerzy Lorenz
- Katedra i Klinika Urologii AM we Wrocławiu
Kierownik Kliniki: prof. dr hab. med. Jerzy Lorenz
Oddział Urologii Wojewódzkiego Szpitala Specjalistycznego we Wrocławiu
Ordynator: prof. dr hab. med. Jerzy Lorenz
Zakład Immunologii Nowotworów
Instytutu Immunologii i Terapii Doświadczalnej PANwe Wrocławiu
Kierownik: prof. dr hab. Cz. Radzikowski
keywords
-
bladder neoplasms DNA ploidy
summary
- Objective. The aim of the study was to find the correlation between DNA
- ploidy as a tumor marker and the stage, the histopatologie grade and clinical
- course of the disease in bladder cancer patients.
- Material and method. A prospective study of cellular DNA content by flow
- cytometry was performed on bladder irrigation and tissue obtained from 105
- patient with urothelial bladder carcinoma.
- Results. The DNA histogram were classified as diploid (52/105) and
- aneuploid (53/105) with one or more aneuploid cell population. While grade
- 1 transitional cell carcinoma were with few exceptions diploid and grade 3
- aneuploid, about half of grade 2 tumors were diploid or aneuploid. A significant
- correlations were found: beetwen T category and DNA ploidy - invasive tumors
- were aneuploid, beetwen type of growth and multiplicity of tumors. The results
- of DNA measurement were also related to the clinical course of the disease:
- patients with diploid tumors had very low receurence rate and developed
- almost no progression (mean follow - up 22 months).
- Conclusions. The results of prospective studies of flow cytometry DNA
- analysis indicate DNA ploidy status as a useful complement to the clinical
- and histological classifications of urothelial bladder carcinoma.
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