PTU - Polskie Towarzystwo Urologiczne
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THE ANALYSIS OF THE PROGNOSTIC FACTORS AFFECTING RESPONSE TO RADIATION AND SURVIVAL OF THE PATIENTS WITH BLADDER CANCER
Article published in Urologia Polska 1998/51/3.

authors

Ryszard Krynicki
II Zakład Teleradioterapii Centrum Onkologii
Instytutu im. Marii Skłodowskiej-Curie w Warszawie
Kierownik Zakładu: dr med. J. Fijuth

keywords

bladder bladder cancer radiotherapy Prognostic factors ? survival

summary

Introduction. The management of the patients with bladder cancer remains
controversial. There are no clear ? cut indications in the literature as to which
patients or which tumours are best selected for management by primary radical
radiotherapy.
Objective. The aim of the study was to identify prognostic factors recognized
with inoperative methods affecting response to radiation and survival.
Material and methods. Three hundred and nine patients with bladder cancer
were treated with definitive radiotherapy, with 4, 9,15 MV photons and cobalt
60 photons, using four field techni±ue. The average total absorbed dose was 60
Gy (range 55-66 Gy). Survival was estimated according to Kaplan-Meier method
and differences between survival curves were assessed by the log-rank test. Cox
regression analysis were used for multivariate analysis.
Results. A prognostic index was derived and three prognostic subgroups were
identified basing on the tumour size, configuration, ureteric obstruction and
haemoglobin level. The prognostic index could divide patients into those with
good, moderate and poor prognosis. The 5 year survival rate for patients in the
poor prognosis group was 12% compared to 53% for patients in the good prognosis
group (p < 0.0001).
Conclusions. The prognostic factors recognized with inoperative methods were:
tumour size, configuration, ureteric obstruction and haemoglobin level.

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