THE ANALYSIS OF THE PROGNOSTIC FACTORS AFFECTING
RESPONSE TO RADIATION AND SURVIVAL
OF THE PATIENTS WITH BLADDER CANCER
Article published in Urologia Polska 1998/51/3.
authors
-
Ryszard Krynicki
- II Zakład Teleradioterapii Centrum Onkologii
Instytutu im. Marii Skłodowskiej-Curie w Warszawie
Kierownik Zakładu: dr med. J. Fijuth
keywords
-
bladder bladder cancer radiotherapy Prognostic factors ? survival
summary
- Introduction. The management of the patients with bladder cancer remains
- controversial. There are no clear ? cut indications in the literature as to which
- patients or which tumours are best selected for management by primary radical
- radiotherapy.
- Objective. The aim of the study was to identify prognostic factors recognized
- with inoperative methods affecting response to radiation and survival.
- Material and methods. Three hundred and nine patients with bladder cancer
- were treated with definitive radiotherapy, with 4, 9,15 MV photons and cobalt
- 60 photons, using four field techni±ue. The average total absorbed dose was 60
- Gy (range 55-66 Gy). Survival was estimated according to Kaplan-Meier method
- and differences between survival curves were assessed by the log-rank test. Cox
- regression analysis were used for multivariate analysis.
- Results. A prognostic index was derived and three prognostic subgroups were
- identified basing on the tumour size, configuration, ureteric obstruction and
- haemoglobin level. The prognostic index could divide patients into those with
- good, moderate and poor prognosis. The 5 year survival rate for patients in the
- poor prognosis group was 12% compared to 53% for patients in the good prognosis
- group (p < 0.0001).
- Conclusions. The prognostic factors recognized with inoperative methods were:
- tumour size, configuration, ureteric obstruction and haemoglobin level.
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