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THE ROLE OF GABA-ERGIC SYSTEM IN BLADDER AND PROSTATE CARCINOGENESIS ? PRELIMINARY STUDY
Article published in Urologia Polska 1998/51/4.

authors

Dariusz Borowiec, Tadeusz Spruch, Maria Juszkiewicz 1
Katedra i Klinika Urologii AM w Lublinie
Kierownik Kliniki: prof. dr hab. T. Spruch
Katedra i Zakład Farmakologii AM w Lublinie
Kierownik Katedry: prof. dr hab. Z. Kleinrok

keywords

urinary tract neoplasms carcinogenesis GABA-ergic system

summary

Objective. The paper presents the preliminary study dealing with the role of
GABA-ergic system in the bladder and prostate carcinogenesis. The differences
between y-aminobutyric acid (GABA) metabolism in the bladder cancer in
Comparison with control group, i.e., physiological bladders without any
patologic changes, were examined. The GABA contents and glutamic acid
decarboxylase (GAD) activity was also determined in prostate cancer and benign
prostatic hyperplasia (BPH).
Material and methods. The 22 biopsies from the bladder wall (11 ? carcinoma
urotheliale, 11 control group ? bladders without patologic changes) and 14
biopsies from prostate (6 ? adenocarcinoma prostatae, 8 ? adenomyomatosis
prostatae) were treated as study materials. They were obtained during surgical
procedures. In -each case, diagnosis was confirmed by histopathological
examination. GABA level and GAD activity were determined according to
spectrofluorimetric method by Lowe in modification by Sutton.
Results. The significant (p < 0.001) increase in GABA level was determined
in bladder cancer (256.79 (ig/1 g tissue) in Comparison with physiological
bladders (102.14 ug/1 g tissue). In carcinoma urotheliale GAD activity was
significantly (p < 0.001) higher (256.42 ng GABA/1 g tissue/l h) vs. control
group (137.53 ng GABA/1 g tissue/lh). The high GABA contents was reported
both in BPH (286.06 ng/Ig tissue) and prostate cancer (316.76 ng/l g tissue) as
well as the increased GAD activity (277.62 ng/GABA/1 g tissue/l h in BPH
and 317.60 ng GABA/1 g tissue/l h in prostate cancer).
Conclusions. GABA-ergic system apears to exhibit changed activity in cancer
tissues. Treatment supplementation with GABA-agonists seems to be beneficial
for its final result.

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