PATHOLOGICAL CHANGES IN THE PROSTATE
OF THE PATIENTS TREATED FOR BLADDER CANCER
Article published in Urologia Polska 1999/52/1.
authors
-
Tomasz Demkow 1, Anna Nasierowska-Guttmejer 2, Paweł Wiechno 1, Grzegorz Madej 1
- 1 Klinika Nowotworów Układu Moczowego Instytutu Onkologii w Warszawie
Kierownik Kiliniki: prof. dr hab. G. Madej
2 Zakład Patomorfologii Instytutu Onkologii w Warszawie
Dyrektor Instytutu: prof. dr hab. n. med. A. Kułakowski
keywords
-
prostate transitional cell carcinoma adenocarcinoma granuloma
summary
- Objective. The aim of the study is to assess pathological changes in the
- prostate of patients treated for bladder cancer.
- Material and methods. 62 patients underwent radical cystoprostatecto-
- my for advanced bladder cancer. Before surgery 11 patients received neo-
- adjuvant systemic chemotherapy, 3 patients had radiotherapy (patients re-
- fused cystectomy), 3 patients had neoadjuvant systemic chemotherapy and
- radiotherapy, 6 patients underwent BCG bladder instillations for superfi-
- cial bladder cancer, 2 patients had BCG bladder instillations and systemic
- chemotherapy. The specimens has been fixed in the paraffin and stained
- with hematoxilin eosin. The pathological changes has been assessed accor-
- ding to TNM classification.
- Results. In 23 specimens no pathological changes were found in prostate
- gland. In this group clinical stages has been assessed as following: 7 pa-
- tients - T3G2N()M()/ 4 patients - T2G2N0M0, 8 patients - T3G3N()M0, 4 pa-
- tients T2G3N()M0. In 7 specimens transitional cell carcinoma of the bladder
- invaded the prostate through the bladder wall (clinical stages ? 1 patient
- T2G3N0M() , 2 patients T3G2N()MU , 4 patients T3G3N0M()). In 11 specimens
- clinical stages ? 1 patient T2G2N0M(), 3 patients T2G3N(
- T3G2N0M0), 3 patients T3G3NQM0) separate foci of cancer in the bladder and
- prostate has been found. In situ component has been found in: prostatic
- urethra in 2 patients, periurethral glands in 3 patients, prostatic ducts and
- acini in 3 patients, stroma in 3 patients. Adenoca of the prostate was iden-
- tified in 9 specimens (5 patients pTH, 3 patients pT]b, 1 patient pT2). Multi-
- focal intraepithełial neoplasia ? PIN was present in 3 specimens. In this
- group clinical stages of bladder carcinoma has been assessed: 4 patients
- - T2G3N0M0, 5 patients - T3G2N()M{), 3 patients T3G3N()M()). In 9 prostate
- glands (clinical stages of the bladder cancer: 1 patient T3G3N()M0, 4 patients
- T3G2, 4 patients T2G2N0M0) granulomas were present: 4 patients after intra-
- vesical BCG instillations, 3 patients after neoadjuvant systemic chemothe-
- rapy, and 2 patients after intravesical BCG instillations and neoadjuvant
- chemotherapy. Before treatment serum PSA level has been estimated in 22
- patients.
- Conclusions. 1. Adenocarcinoma and transitionall cell carcinoma of the
- prostate fre±uently coexists with transitional cell carcinoma of the bladder.
- 2. TCC of the prostate gland derives from urethra, periurethral glands, acini
- and stroma. 3. Following BCG intravesical instillations granulomas were very
- often identified in the prostate gland.
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