LOW T3 SYNDROME IN PATIENTS SUFFERING
FROM RENAL CELL CLEAR CARCINOMA (RCC).
THE DEPENDANCE ON ITS DIAMETER (T) AND GRADING (G)
Article published in Urologia Polska 2000/53/3.
authors
-
Zbigniew Tański
- Zakład Biochemii Klinicznej Studium Nauk Podstawowych
Centrum Medycznego Kształcenia Podyplomowego w Warszawie
Kierownik: prof. dr hab. A. Macke-Nauman
keywords
-
kidney renal clear carcinoma (RCC) low T3 syndrome
summary
- Objective. Low T3 syndrome is characterized by the decrease in tT3 level
- and fT3 level, the normal level of tT4 and fT4 and TSH level situated within
- the norm. The pathogenesis of low T3 syndrome has not been entriely
- recognized yet.
- Material and method. The course of low T3 syndrome in patients suffering
- from RCC was examined before, during and after radical nephrectomy. It
- was explained if the concentration of tT3 in blood depends on the grading
- and the diameter of the tumour. The concentration of tT3 and tT4 in blood of
- the renal artery and vein in the neoplastic kidney and peripheral vein was
- determind. It was done depending on the diameter (T) and grading (G) of
- the tumour. The research was applied to 54 patients (20 F, 34 M) at the age
- from 27 to 72 suffering from RCC, who were treated at the Urological Word
- of the United Provincial Hospital in Ostrołęka. The patients were divided
- into groups depending on the diameter of the tumour T (Ta-T4), and grading
- G (GrG3). Concentrations of TSH, tT4, fT4, tT3 and fT3 in the blood serum
- were determined. The blood was collected from the renal artery and vein,
- peripheral vein of the patients suffering from RCC on the day of their
- admission to the Ward, 30 minutes before the operation, during the operation
- as well as 30 minutes after it. It was also collected from the peripheral vein 1,
- 2, 5, 7, 30 and 60 days after the operation. Hormones were determined with
- the help of Abbott IMX, MEIA system.
- Results. The obtained results of the research point out that RCC leads to the
- pathogenesis of low T3 syndrome. Low T3 syndrome depends on the diameter
- of the tumour and its grading. No significant differences in arterio-venous
- gradients of tT3 concentration (renal artery and vein) were found. tT3 in
- renal artery was higher than in renal vein. The low T3 syndrome in RCC
- depends on the decrease in the level of de novo generated tT3 in neoplastic
- cells and restricting the conversion of tT4 to tT3 in alt cells of the body.
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