CODE: 7.2 - Oncological features of T1c prostate cancer
Article published in Urologia Polska 2006/59/Suplement 1.

authors

Gerard Grotthuss ¹, Jakub Dobruch ¹, Przemysław Szostek ¹, Artur A. Antoniewicz ¹, Piotr Chłosta ², Andrzej Borówka ¹

¹ Klinika Urologii Centrum Medycznego Kształcenia Podyplomowego, I Zespół Dydaktyki Urologicznej - Oddział Urologii Międzyleskiego Szpitala Specjalistycznego w Warszawie
² Oddział Urologii, Świętokrzyskie Centrum Onkologii w Kielcach

summary

Introduction. Prostate cancer is one of the most prevalent malignancies in men. Wide-spread serum prostate specific antigen measurements introduced in early nineties resulted in a marked stage migration. In current series radical prostatectomy is performed mainly in men with newly diagnosed prostate cancer who had no abnormality on digital rectal examination (T1c).

Objectives. The authors examined clinical and pathological variables in patients with T1c prostate cancer and compared them with features of patients subjected to radical prostatectomy due to other than T1c prostate cancer.

Materials and methods. From January 2001 to May 2005, 107 men underwent radical prostatectomy due to clinically organ confined prostate cancer. Digital rectal examination was unsuspected for prostate cancer in 42 (39%) of them. The relationship between T1c and other clinical and pathologic features was tested.

Results. In comparison to men with other then T1c prostate cancer, men with T1c PCa had lower PSA (9.8 ? 2.0 vs 6.9 ? 1.4, NS) and PSAD values (0.29 ? 0.49 vs 0.26 ? 0.23, NS). They also had lower biopsy (5.4 ? 1.8 vs 4.9 ? 1.8, NS) and specimens Gleason score (5.8 ? 2.3 vs 5.2 ? 1.4, NS) and prostate cancer percent in biopsy cores (65.3 ? 4.5 vs 46.6 ? 8.4, NS), but these differences did not reach the level of significance. The patients with T1c prostate cancer were less likely to have concomitant extracapsular extension (52% vs 69%), seminal vesicle invasion (7.1% vs 10.8%).

Conclusions. Radical prostatectomy performed in men due to cancer which has no abnormality on digital rectal examination is associated with favorable outcome. Men with T1c prostate cancer constitute the low risk group of patients.