PTU - Polskie Towarzystwo Urologiczne
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Adjuvant postoperative inguinal nodes irradiation in patients with penis cancer
Article published in Urologia Polska 2001/54/3.

authors

Piotr Pęczkowski, Małgorzata Pilichowska
Klinika Nowotworów Układu Moczowego, Centrum Onkologii-Instytutu im. Marii Skłodowskiej-Curie, Warszawa Kierownik kliniki: dr med. Tomasz Demkow

keywords

penis, penile cancer, lymph, radiotherapy

summary

Objective. To study of effectiveness an toxicity adjuvant postoperative inguinal nodes irradiation in the patients with squamosus cell penis cancer.
Material and methods. Between 1986 and 1999 17 patients with the risk of subclinical disease in the inguinal nodes after the groin lymph nodes dissection underwent adjuvant radiotherapy. The median age at treatment was 59 years. The median follow up was 12 months. The patients were treated with cobalt beams to the pelvic nodes and then the electron boost to the groin was done.
Results. Nine patients died during the follow up period. We noticed for recurrences but two were outside of the irradiation field. The actuarial 3-year survival rates were as follows: overall non-specific survival 41%, disease-free survival 55% and local relapse-free survival 73,5%. The acute and late complications of irradiation were minimal.
Conclusion. Adjuvant irradiation of inguinal nodes means effective in controlling subclinical disease from penis cancer. The toxicity of our radiotherapy technique was very low.

references

  1. 1. Bouchot O, Auvignc J, Peuvrcl P, Glemain P, Buzelin JM: Ma nagement of regional lymph nodes in carcinoma of the penis. Eur Urol 1989; 16; 410-415.
  2. 2. Persky L: Epidemiolog}\\\' of cancer penis. Recent Results Cancer Res 1977; 60; 97-109.
  3. 3. Zatoński W, Tyczyński J: Nowotwory złośliwe w Polsce w 1991 roku. Centrum Onkologii-Instytut, Warszawa 1991; 56.
  4. 4. Fralcy EE, Zhang G, Manivel C, Niehans GA: The role of ilioinguinal lymphadeneciomy and significance of histological differentiation in treatment of carcinoma of the penis. J Urol 1989; 142; 1478-1482.
  5. 5. Horenblas SH, Tintercn H, Delemaree JFM, Moonen LMF, Lustig V,Waardenburg EW: Squamosus cell carcinoma of the penis. III. Treatment of regional lymph nodes. J Urol 1993; 149; 492-497.
  6. 6. Ornellas AA, Seixas ALC, Marota A, Wisnescky A, Campos S, De Moracs JR: Surgical treatment of invasive squamous cell carcinoma of the penis: Retrospective analysis of 350 cases. J Urol 1994; 151; 1244-1249.
  7. 7. Kulkami JN, Kamat MR: Prophylactic bilateral groin node dissection versus prophylactic radiotherapy and surveillence in patients with No and N1-2A carcinoma of the penis. Eur Urol 1994; 26; 123-128.
  8. 8. Narayana AS, Olney LE, Loening SA, Weimar GW, Culp DA: Carcinoma of the penis. Analysis of 219 cases. Cancer 1982; 49; 2185-2191.
  9. 9. Rozan R, Albuisson E, Giraud B, Donnaricx D, Delannes M, Pigneux J, Hoffstetter S, Gerbaulet A, Chinct-Carol P, Goupil A, Couette JE, Hay MH, Chaplain G, Castclain B, Hassel B, Mere P, Cellier P: Interstitial brachytherapy for penile carcinoma. A multicentric survey. Radiolher Oncol 1995; 36; 83-93.
  10. 10. Young MJ, Reda DJ, Waters WB: Penile carcinoma: a twenty-five years experience. Urology 1991; 38; 528-532.
  11. 11. Solsona E, Iborra I, Ricos JV, Monros JL, Dumont R, Casanova J, Calabuig C: Coipus cavernosum invasion and tumor grade in the prediction of lymph node condition in penile carcinoma. EurUro! 1992; 22; 115-118.
  12. 12. Killie AE, Elwell C, Close HJ, Ash DV: Ińdium-192 implantation for node-negative carcinoma of the penis: The Cookridge Hospital experience. Clin Oncol 2000; 12: 25-31.
  13. 13. Łyczek J: lirachyterapia w urologii onkologicznej. Terapia 1998; 6; 11-12.
  14. 14. Ravi R, Chaturvedi HK, Sastry DVLN: Role of radiation therapy in the carcinoma of the penis. Br J Urol 1994; 74; 646-651.
  15. 15. Gerbaulet A, Lambin P: Radiation therapy of cancer of the penis. Indications, advantages, and pitfalls. Urol Clin North Am 1992; 19; 325-332.

correspondence

Piotr Pęczkowski
Klimka Nowotworów Układu Moczowego
Centrum Onkologii - Instytut im. Marii Skłodowskiej Curie
ul. Roentgena .5
02-781 Warszawa