PTU - Polskie Towarzystwo Urologiczne
list of articles:

Human serum dopaminę beta hydrozylase activity in benign prostatic Hypertrophy Patients
Article published in Urologia Polska 1994/47/4.

authors

Tadeusz Spruch, Robert Klijer
Z Kliniki Urologii Akademii Medycznej w Lublinie
Kierownik: Prof. dr hab. med. T. Spruch

summary

Human serum dopaminę beta hydroksylase activity has been described in patients with
benign prostatic hypertrophy. This enzyme is regarded as sensitive index of sympathetic
nenrous system activity in man. This study was aimed to investigate relationships between
tympathoadrenal activity and clinical symptoms due to prostatic obstruction. 55 patients were
dmded into 3 groups: I group 30 patients with BPH, II group 15 patients with acute abstruction
due to BPH, III group 10 patient with urethrostenosis and 10 patients as control group. The
DBH activity was 31,8 I.U. (±9,5 SD) in group I, 32,25 I.U. (±12,9 SD) in group II, 29,29
I.U. (±18,4 SD) in group III and 31,9 LU. (±24,7 SD) in control group. There was no
significant corelation between human serum dopaminę beta hydroksylase activity and degree of
prostatic obstruction.

references

  1. 1. Amark P., Kirm A.C., Nergardh A.: Receptor function studies in specimens from the prozimal human urethra obtained by transurethral resection. Urol. Res. 1992, 20, 1, 55. —
  2. 2. Caine M.: Alpha adrenergic mechanism in dynamics of benign prostatic hyperthrophy. Urology. 1988, 32, 6, 16.
  3. 3. Chapple CR., Aubry M.L., James S., Greengrass P.M., Burnstock G., Turner Warwick R.T., Milroy EJ., Dawey M.J.:Characterisation of human prostatae adrenoceptors using pharmacology receptor binding and localistion. Br. J. Urol. 1989, 63, 5, 487. —
  4. 4. Christenson M.M., HolmeJ.B., Rasmussen P.C.,Jacobsen F., Nielsen J.,NorgaardJ.P. Olsen P., Noer I., Wolf H., Husted S.E.: Doxazosin treatment in patients with prostatic obstruction. Scan. J. Urol. Nephrol. 1993, 27, 39. —
  5. 5. Gup D.I., Shapiro E., Baumann M., LeporH.: Autonomie receptors in human adenomas. J. Urol., 1990, 143, 1, 179. —
  6. 6. Horowitz £>.: Human serum dopaminę beta hydroxylaze relationship to hypertension and sympathetic activity. Circ. Res., 1973, 32, 594. —
  7. 7. James S., Chapple CR., Phillips M.I., Greengrass P.M., Davey M.J., Turner Warwick R.T., Milroy E.J., Burnstock G.: Autoradiographic analysis of alpha adrenoceptors and muscarinic cholinergic receptors in the hyperplastic human prostatae. J. Urol., 1989,142, 2,438. —
  8. 8. Kawabe K., Moriyama N., Hamada K., Ishima T.: Density and localisation of alpha 1 adrenoceptors in hypertrophied prostate. J. Urol., 1990,143, 3, 592. —
  9. 9. Lepor H., Gup Dt., Baumann M., Shapiro E.: Comparison of alpha 1 adrenoceptors in the prostate capsule of men with Symptomatic and asymptomatic benign prostatic hyperplasia. Br. }. Urol., 1991, 67, 5, 493. —
  10. 10. Lepor H., Gup Di., Baumann M., Shapiro E.: Laboratory assessment of Terazosin and alpha 1 blockade in prostatic hyperplasia. Urology., 1988, 32, 6, 21.
  11. 11. Ltpor H., Shapiro E.3 Bowsher R.R., Henry D.P.: Determination of norepinephrine levels in the adult human prostate. J.Urol. 1990, 144, 5 1263. —
  12. 12. Milroy E.: Clinical overview of prazosin in the treatment of prostatic obstruction. Urol. Int, 1990, 45, 1,1. —
  13. 13. Nagatsu T., Udenfriend S.: Photometric assay of dopaminę beta hydroxylase activity in human blood. Clin. Chem., 1972, 18, 980. —
  14. 14. Noth R.H., Mtdrow P.J.: Serum dopaminę beta hydroxylase as an index of sympathetic nervous system activity in man. Circ. Res., 1976, 38, 2.
  15. IS. Shapiro E., Ltpor H.: Alpha 2 adrenergic receptors in hyperplastic human prostate. Identification and characterization using 3H rauwolscine. J. Urol., 1986, 135, 5, 1038. —
  16. 16. Traczyk W., Trzebski A.: Fizjologia człowieka z elementami fizjologii stosowanej i klinicznej.PZWL, Warszawa, 1990,1, 342. —
  17. 17. Weinskilboum RM.: Serum dopaminę beta hydroxylase. Pharmacol Rev., 1979, 30, 133. —
  18. 18. Yamada S.3 Ashizawa N., Ushijima H., Nakayama K., Hayashi E., Honda K.: Alpha 1 andrenoceptors in human prostate, characterization and alteration in benign prostatic hypertrophy. J. Pharmacol. Exp. Ther., 1987, 242,1, 326. 19. Yasuda K., Nagashima K., Murayama N., Yamanishi T., Tojo M., Shimazaki J.\\\\ Chage of ejcternal urethral sphincter function in prostatic patients. Urol. Int., 1991, 4T, 1, 43. —
  19. 20. Zieliński J., Leńko J.: Urologia Kliniczna. PZWL, Warszawa. 1993, 2, 52.

correspondence

prof. dr hab. med. Tadeusz Spruch
Klinika Urologii
20-950 Lublin, ul. JaczewsMego 8