PTU - Polskie Towarzystwo Urologiczne
list of articles:

Chemoprevention of prostate cancer – new perspectives?
Article published in Urologia Polska 2008/61/3.

authors

Zbigniew Jabłonowski
I Klinika Urologii Katedry Urologii Uniwersytetu Medycznego w Łodzi

keywords

prostate prostate cancer chemoprevention finasteride PCPT study

summary

In Poland the amount of newly diagnosed prostate cancers increases systematically with the number of 7095 cases in 2005. It is
estimated that 200 000 men are diagnosed with prostate cancer in the USA annually and about 90% of them receive treatment for
it. The Prostate Cancer Prevention Trial (PCPT) was the first prospective, randomized, placebo-controlled clinical trial of prostate cancer
chemoprevention. Initial results of the study showed a greater proportion and number of histologically high-grade carcinomas. A new
analysis from the Prostate Cancer Prevention Trial shows that finasteride does not increase the risk for high-grade prostate cancer. The
latest data from 2008 demonstrate that chemopreventive treatment with finasteride for 7 years decreases the incidence of prostate
cancer by an estimated 30%, without increasing the incidence of high-grade tumours. The new analysis shows how small differences
in biopsy sensitivity between the study arms could results in the apparent finasteride-assosiated increase in high-grades on biopsy
that was reported in 2003. The findings of the PCPT seem to provide the foundation for the further studies on chemoprevention of
prostate cancer.

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correspondence

Zbigniew Jabłonowski
I Klinika Urologii UM
ul. Żeromskiego 113
90-549 Łódź
tel. (042) 636 82 14
zby_szek@tlen.pl