PTU - Polskie Towarzystwo Urologiczne
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Evaluation of results of combined treatment (chemotherapy and radiotherapy) of patients with stage II testicular seminoma
Article published in Urologia Polska 2004/57/1.

authors

Małgorzata Pilichowska, Piotr Pęczkowski, Beata Paluchowska, Paweł Wiechno, Iwona Skoneczna, Tomasz Demkow
Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie w Warszawie,
Klinika Nowotworów Układu Moczowego
Kierownik kliniki: doc. dr hab. Tomasz Demkow
Dyrektor Centrum Onkologii – Instytutu: prof. dr hab. Marek Nowacki

keywords

testis, testicular seminoma, chemotherapy treatment, radiotherapy treatment

summary

introduction
There are 15% and 40% relapse rate in patients after archiectomy and radiotherapy with non-bulky stage II (IIA+IIB) and with stage IIC respectively. Different combined treatment protocols are tested in many centers.
material and methods
The retrospective analysis of 85 patients treated between 1985 and 1997 was performed. The age was between 22 and 59 months, median diameter of tumor was 7cm (1-20). After orchiectomy chemotherapy was administered: median number of cycles was 3 (1-6), PVB – 32 pts, BEP – 34 pts, CEB – 6 pts, Carboplatin – 12 pts, 1pts VAB – 6. After chemotherapy radiation treatment was given with median dose 30,5 Gy (11-50 Gy), radiation fields included paraaortic and ipsilateral iliac lymph nodes, 1 patient had mediastinal field and 1 pt supraclavicular field.
results
In the median time of observation 90,7 months (2-181) 90,6% of patients are alive and disease free, 8 pts (9,4%) died, 6 of them (7,1%) in the course of disease progression (PD). PD was observed in 9 pts (10,6%), time to progression was 6-58 months. Treatment toxicity was acceptable, most frequently anemia and nausea were seen, radiation tolerance was good except one case - toxic deaths in course of RTH due to significant radiation overdose.
conclusions
Combined treatment (chemotherapy and radiotherapy) in patients with stage II seminoma is highly effective and feasible.

references

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correspondence

Małgorzata Pilichowska
Klinika Nowotworów Układu Moczowego
Centrum Onkatogii-Instytut im. Marii Sklodowskiej-Curie
02-781 Warnom
ul. Roentgena 5
tel.: (0-22) 546 25 270