PTU - Polskie Towarzystwo Urologiczne
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SUSCEPTIBILITY TO OFLOXACIN AND OTHER CHEMOTHERAPEUTIC AGENTS IN BACTERIAL STRAINS ISOLATED FROM URINE
Article published in Urologia Polska 1990/43/3.

authors

Janina Ruczkowska, Izabela Dolna
Z Katedry i Zakładu Mikrobiologii Lekarskiej AM we Wrocławiu Kierownik: prof. dr hab. med. K. Grzybek-Hryniewicz

summary

In vitro activity of ofloxacin against 741 bacterial strains isolated from urine of haspitalized patients was compared with that of nalidixic acid, nitrofurantoin and co-trimoxazole.
Ofloxacin proved to be the most aietive drug against over 90,0°/o of isolated Staphylococci and Enterobacteriacae strains. Less sensitive were Pseudomonas aeruginosa (44,7°/o) and other nonfermentative Gram-negative bacilii (88,9%).
In general, ofloxacin was shown to be superior to nalidixic acid, nitrofurantoin and cotrimoxazole against Gram-negative rods, and equal to nitrofurantoin against Staphylococci.

references

  1. 1. Auckenthaler R., Michea-Hamzehpour, Pechere 3. C: In vitro activity of newer quinolones against aerobic bacteria. J. antimicrob. Chemother., 1986, 17, Supl. B, 29. ? 2. Bauer A. W., Kirby J. C, Sherris J. C, Turck M.: Antibiotic sus-ceptibility testing by standardised single disc method. Am. J. clin. Pathol., 1966, 45, 492 ? 3. Block J.M., Walstad R. A., Bjertnaes Aa., Hafstad P.E., Holte M., Ot-temo I., Svarva P. L., Rolstadt T., Peterson L. E.: Ofloxacin versus trimethoprim--sulp;haimelthoxaiaole in acute cystitis. Drugs, 1987, 43, Supl. 1, 100. ? 4. Giama-eellou H., Tsagarakis J.: Efficacy and tolerance of oral ofloxacin in treating ya­rious infections. Drugs, 1987, 34, Suppl. 1, 119. ? 5. Gruneberg R. N., Felmingham D., O'Hare M. D., Robbins M. J., Perry K., Wall R. A., Ridgway G. L.: The compa-rative in vitro activity of ofloxacin. J. antimicrob. Chemother., 1988, 22, Suppl. C, 9. ? 6. Jungst C, Mohr R.: Overview of postmarketing experience with ofloxacin in Germany. J. antimicrob. Chemother., 1,988, 22, Suppl. C, 167. ? 7. Kazimier-czak J., Samborska A., Kruszewska H., Makuch I., Ryznar T.: Nowe chinoliny o działaniu przeciwbakteryjnym. Biul. Inf. Inst. Frmaceut,, 1986, 34, 11. ? 8. Kromann-Andersen B., Sommer P., Pers C, Larsen V., Rasmussen F.: Ofloxacin compared with ciprofloxacin in the treatimenit of complicated lower urinary in­fections. J. antimicorb. Chemother., 193'8, 22, Suppl. C, 143. ? 9. Ludwig G., Pauth-ner H.: Clinical experience with ofloxacin in upper and lower urinary tract in­fections: A Comparison with co-trimoxazole and nitrofurantoin. Drugs, 1987, 34, Suppl. 1, 95. ? 10. Osada Y., Ogawa H.: Antimycoplasmal activity of ofloxacin (DL-8280). Antimicrob. Agents Chemother., 1983, 2:3, 509.
  2. 1,1. Richmond S. J., Bhattacharyya M. N., Maiti M., Chowdhury F. H., Stirland R. M., Tooth J. A.: The efficacy of ofloxacin against infection caused by Neisseria gonorrhoeae and Chlamydia trachomatis. J. antimicrob. Chemother., ,1988, 22, Suppl. C, 1419. ? 12. Ruczkowska J., Choroszy-Król I.: Wyniki 5-dniowego leczenia oflo­ksacyną (Tarivid) chlamydialnego zapalenia cewki moczowej u mężczyzn. Przeg. Derm., 1990, 77, 143. ? 13. Ruczkowska J., Dolna L: Wrażliwość klinicznych szcze­pów bakteryjnych na ofloksacynę i niektóre antybiotyki. Przeg. Lek. 1990 (w dru­ku). ? 14. Ruczkowska J., Dolna I., Choroszy-Król L: Flora bakteryjna towarzy­sząca chlamydialnemu zapaleniu cewki moczowej u mężczyzn przed i po leczeniu ofloksacyną. Przeg. Derm., 1990, 77, 186. ? 15'. Rugndorff E. W.: Open rando­mised comprised of ofloxacin and norfloxacin in the treatment of complicated urinary tract infections. Drugs, 1987, 34, Suppl. 1, 91. ? 16. Sabbour M. S., Osman L. M., Abd-El-Hamid T., El-Baz W. E.: Present day susceptibility of urinary partho-gens to antimicrobials. Drugs, 198,7, 34, Suppl. 1, 176. ? 17. Seibert G., Limbert M., Klesel N.: Comparison of the antibacterial in vitro and in vivo activity of oflo-xacin (HOE 280 DL 8280) and nalidixic acid analogues,. Eur. J. clin. Microbiol., 1983, 2, 548. ? 1,8. Walker R. C, Wright A. J.: The quinolones. Mayo Clin. Proc, 1987, 62, 1007. ? 19. Wise R., Lockley M. R.: The pharmacokinetics of ofloxacin and a review of its tissue penetration. J. antimicrob. Chemother., 1,988, 22, Suppl. C, 50.